RBRC02300, B6.129P2-Pten<tm2Mak>

RBRC No. RBRC02300
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129P2-Pten<tm2Mak>
Former Common name Pten-flox mouse (C57BL/6)
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Tak W. Mak, Ontario Cancer Institute in 2001. Deposited by Dr. Shigeo Koyasu, Keio University School of Medicine. C57BL/6N background.
Strain description Pten is a lipid phosphatase associated with tumor suppression. This conditional knockout mice have a loxP-flanked Pten allele. Conditional Pten deficient mice can be generated by crossing with tissue-specific Cre mice.
Colony maintenance backcross to C57BL/6 (Heterozygote x C57BL/6NTac)
Health Report
Gene Details
Promoter No Data
1 Symbol Pten
Symbol name phosphatase and tensin homolog
Chromosome 19
Common name 2310035O07Rik, A130070J02Rik, MMAC1, TEP1
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 19
Common name No Data
Symbol description No Data

Research applications Cancer Research,
Cell Biology Research,
Cre/loxP system,
General Purpose
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOER (Tak W. Mak Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca).
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Koyasu, Shigeo (Keio University) Koyasu, Shigeo
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
Regulation of RhoA by STAT3 coordinates glial scar formation. J. Cell Biol.216(8): 2533-2550 (2017).(28642362)
Renault-Mihara F, Mukaino M, Shinozaki M, Kumamaru H, Kawase S, Baudoux M, Ishibashi T, Kawabata S, Nishiyama Y, Sugai K, Yasutake K, Okada S, Nakamura M, Okano H.
Generation of transgenic mouse line with prostate-specific expression of codon-improved Cre recombinase. Prostate Int. (2018).(30140659)
Mayuko Kanayama, Kazuki Nakao, Shigeo Horie, Atsu Aiba.