RBRC02323, B6JNrs.129S6-Atm<tm1Awb>/NrsFnt

RBRC No. RBRC02323
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6JNrs.129S6-Atm<tm1Awb>/NrsFnt
Former Common name B6-Atm knock-out mice
H-2 Haplotype No Data
Background strain C57BL/6JNrs
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development The targeted alle was developed by Dr. A. Wynshow-Boris, NHI. The mutant mice were introduced into NRS in 1997, and then generated the Atm KO mice of C57BL/6 background by backcrossing to C57BL/6JNrs for 16 times.
Strain description Atm, ataxia telangiectasia mutated homolog (human) gene knockout mice. Homozygous mutant mice disrupted Atm gene exhibit growth retardatuin, neurologic dysfunction, infertility, defects in T lymphocyte maturation.
Colony maintenance Sibling Mating (Heterozygote x Wild-type)
Health Report
Gene Details
Promoter No Data
1 Symbol Atm
Symbol name ataxia telangiectasia mutated homolog (human)
Chromosome 9
Common name C030026E19Rik
Symbol description No Data
Promoter human phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name neo; neomycin;
Symbol description No Data
References Cell. 1996 Jul 12;86(1):159-71.

Atm-deficient mice: a paradigm of ataxia telangiectasia.
Research applications Cancer Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Cell. 89, 159-171 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowlidgement to Dr. Kouichi Tatsumi is requested.
Additional information
1 Genetic Background
2 Genotyping protocol <PCR>
Depositor Tsuji, Hideo (National Institute of Radiological Sciences) Tsuji, Hideo
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months