RBRC02330, NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>

RBRC No. RBRC02330
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name NOD.Cg-Fcer1g<tm1Rav> Fcgr2b<tm1Ttk>
Former Common name NODFcγRnull
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance albino
Genotype A/A c/c
Strain development Developed by Drs. Y. Inoue and T. Takai, Tohoku University in 2004.
Strain description FcR common gamma-chain (Fc-Rgamma) deficient mice. NOD background.
Colony maintenance Sibling Mating (Homozygote x Homozygote)
This strain shows less severe insulitis, whereas after the onset of diabetes, homozygous and wild-type mice shows cimparable nsulitis indices.
Health Report
Gene Details
Promoter No Data
1 Symbol Fcer1g
Symbol name Fc receptor, IgE, high affinity I, gamma polypeptide
Chromosome 1
Common name Fce1g, FcR-gamma, FcR[g], FcRgamma, Ly-50
Symbol description No Data
2 Symbol Fcgr2b
Symbol name Fc receptor, IgG, low affinity IIb
Chromosome 1
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References J Immunol. 2007 Jul 15;179(2):764-74.

Activating Fc{gamma} Receptors Participate in the Development of Autoimmune Diabetes in NOD Mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Immunol., 179, 764-774 (2007).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takai, Toshiyuki (Tohoku University) Takai, Toshiyuki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Agonistic Anti-CD40 Induces Thyrocyte Proliferation and Promotes Thyroid Autoimmunity by Increasing CD40 Expression on Thyroid Epithelial Cells. J Immunol. (2013).(23509363)
Kayes T, Fang Y, Yu S, Downey E, Wang S, Braley-Mullen H.