RBRC02339, B6.Cg-Tg(Tec-p210 BCR/ABL1)1Homy

RBRC No. RBRC02339
Type Transgene CongenicCartagena wks
Species Mus musculus
Strain name B6.Cg-Tg(Tec-p210 BCR/ABL1)1Homy
Former Common name p210 Tg
H-2 Haplotype No Data
Background strain C57BL/6NCrlCrlj
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Honda and Hirai, University of Tokyo in 1998.
Strain description This transgenic strain expresses the p210 BCR/ABL1 gene. Tg mice show marked granulocyte hyperplasia and develop myeloproliferative disorders closely resembling human chronic myelogenous leukemia.
Colony maintenance Backcross to C57BL/6 (Hemizygote x C57BL/6NCrlCrlj)
Health Report
Gene Details
Promoter No Data
1 Symbol poly A
Symbol name SV40 poly A siganl
Chromosome UN
Common name No Data
Symbol description No Data
Promoter mouse Tec
2 Symbol BCR/ABL1
Symbol name p210 bcr/abl1 (human)
Chromosome UN
Common name No Data
Symbol description No Data
References Oncogene. 2008 May 29;27(24):3465-74. Epub 2008 Jan 14.


Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Research applications Cancer Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Honda, Hiroaki (Tokyo Women’s Medical University) Honda, Hiroaki
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
NADPH oxidases as therapeutic targets in chronic myeloid leukemia. Clin Cancer Res. (2014).(24833663)
Sanchez-Sanchez B, Gutierrez-Herrero S, Lopez-Ruano G, Prieto-Bermejo R, Romo-Gonzalez M, Llanillo M, Pandiella A, Guerrero C, San Miguel JF, Sanchez-Guijo F, Del Canizo MC, Hernandez-Hernandez A.