RBRC02342, C57BL/6-Gak<tm1Noj>/+

RBRC No. RBRC02342
Type Targeted MutationCartagena
Species Mus musculus
Strain name C57BL/6-Gak<tm1Noj>/+
Former Common name GAK+/-, Cyclin G-associated kinase(GAK) heterozygous mouse
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2007.
Strain description Gak, cyclin G associated kinase gene knockout mice. Exons 2-4 of Gak gene were replaced with a pgk-neo cassette. Homozygous mutant mice die shortly after birth.
Colony maintenance Heterozygote x Wild-type [or Crossing to C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Gak
Symbol name cyclin G associated kinase
Chromosome 5
Common name D130045N16Rik, MGC:31204, GAK-kd
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
References

Research applications Cancer Research,
Cell Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Tabara H et al., “Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction.” PLoS One 2011;6(10):e26034
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months