RBRC02367, B6.Cg-Nr1i2<tm1.1(NR1I2)>

RBRC No. RBRC02367
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Nr1i2<tm1.1(NR1I2)>
Former Common name No Data
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Jun Kanno, National Institute of Health Sciences in 2006. TT2 ES cells were used. The mutant mice were crossed to C57BL/6. Cre- recombined allele (RBRC02367) type mice were generated from Targeted allele type (RBRC02368) mice by crossing with CAG-Cre mice to removed a floxed neo cassette.
Strain description hSXRki mice in which the ligand binding domain (LBD) of human SXR was knocked-into the mouse SXR gene. These umanized mouse model is a useful tool for monitoring the systemic response induced by human-selective SXR ligans. Cre- recombined allele (RBRC02367), Targeted allele type (RBRC02368).
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Nr1i2
Symbol name Nuclear receptor subfamily 1, group I, member 2
Chromosome 16
Common name mPXR, Pregnane X receptor, PXR, PXR.1, PXR.2, SXR
Symbol description No Data
2 Symbol GH
Symbol name Growth hormone polyA (Bovine)
Chromosome 16
Common name No Data
Symbol description No Data
3 Symbol NR1I2
Symbol name Nuclear receptor subfamily 1, group I, member 2(human)
Chromosome 16
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome 16
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Toxicol. Sci., 37, 373-380 (2012).
For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Kanno, Jun (National Institute of Health Sciences) Kanno, Jun
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months