RBRC02378, B6.Cg-Nox1<tm1Cyn>

RBRC No. RBRC02378
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name B6.Cg-Nox1<tm1Cyn>
Former Common name Nox1 KO mouse, Nox1 knockout mouse
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Chihiro Yabe-Nishimura, Kuniharu Matsuno, Kazumi Iwata at Kyoto Prefectual University of Medicine in 2003.
Strain description Nox1 deficient mice. Nox1 gene is a member of the NADPH- dependent superoxide producing enzyme family, which is involved in the production of active oxygen in nonphagocytic cells on the intestine epithelium and vascular smooth muscle.
Colony maintenance Backcross to C57BL/6 (Heterozygous or Hemizygote x C57BL/6CrSlc)
Health Report
Gene Details
Promoter No Data
1 Symbol Nox1
Symbol name NADPH oxidase
Chromosome X
Common name GP91 phox homolog
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome X
Common name neo; neomycin;
Symbol description No Data
References Circulation 2005 Oct 25;112(17):2677-85.

Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice.
Research applications Cardiovascular Research,
Metabolism Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Circulation, 112, 2677-2685 (2005).
The BIOLOGICAL RESOURCE should not be utilized for the application of any patent for commercial purposes without an additional agreement with the DEPOSITOR. The RECIPIENT should not distribute the BIOLOGICAL RESOURCE including any progeny, unmodified derivatives, or any derivatives or genetically engineered modification if such derivative or modification is substantially based on and incorporates an essential element of the BIOLOGICAL RESOURCE to any other individual or entity without the DEPOSITOR’s written consent. The RECIPIENT should inform results obtained using the BIOLOGICAL RESOURCE and discuss the authorship of the work with the DEPOSITOR prior to publication.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Yabe, Chihiro (Kyoto Prefectural University of Medicine) Yabe, Chihiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months