RBRC02388, B6.129P2-Ly96<tm1Kmiy>

RBRC No. RBRC02388
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Ly96<tm1Kmiy>
Former Common name C57BL/6-MD-2 KO
H-2 Haplotype No Data
Background strain No Data
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Ly96
Symbol name lymphocyte antigen 96
Chromosome 1
Common name ESOP-1, MD-2, MD2
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References Nat Immunol. 2002 Jul;3(7):667-72. Epub 2002 Jun 10.

Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature Immunology, 3, 667-672 (2002).
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Miyake, Kensuke (The Institute of Medical Science, The University of Tokyo) Miyake, Kensuke
Strain Status /
(Expected delivery)

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live mouse :
BRC mice in Publications
Title Journal
MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br. J. Pharmacol.172(17): 4391-4405 (2015).(26076332)
Wang Y, Shan X, Chen G, Jiang L, Wang Z, Fang Q, Liu X, Wang J, Zhang Y, Wu W, Liang G.
MD2 Blockage Protects Obesity-Induced Vascular Remodeling via Activating AMPK/Nrf2. Obesity (Silver Spring)25(9): 1532-1539 (2017).(28726347)
Wang L, Han J, Shan P, You S, Chen X, Jin Y, Wang J, Huang W, Wang Y, Liang G.
Blockade of myeloid differentiation protein 2 prevents obesity-induced inflammation and nephropathy. J. Cell. Mol. Med. (2017).(28767204)
Fang Q, Wang L, Yang D, Chen X, Shan X, Zhang Y, Lum H, Wang J, Zhong P, Liang G, Wang Y.
Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis. Biochim. Biophys. Acta1864(1): 252-262 (2017).(28965884)
Fang Q, Wang J, Zhang Y, Wang L, Li W, Han J, Huang W, Liang G, Wang Y.
Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease. J. Cell. Mol. Med. (2017).(29077272)
Zhang Y, Wu B, Zhang H, Ge X, Ying S, Hu M, Li W, Huang Y, Wang L, Chen C, Shan X, Liang G.
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway. Toxicol. Lett.282: 109-120 (2017).(29111459)
Chen H, Song Z, Ying S, Yang X, Wu W, Tan Q, Ju X, Wu W, Zhang X, Qu J, Wang Y.