RBRC02411, B6.129S2-Ptn<tm1Tmu>

RBRC No. RBRC02411
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S2-Ptn<tm1Tmu>
Former Common name Ptn-KO/C57BL/6J
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Muramatsu H. and Muramatsu T., Nagoya University in 2001.
Strain description Pleiotrophin (PTN) knock-out mice, Ptn is a low molecular weight protein that regulates cell growth, survival and migration and other activities of responding cells. Ptn gene strongly expresses in the brain at the later mouse embryogenesis, In the human, it is known that the expression of Ptn gene is observed at the ischemic injury in various cancer.
Colony maintenance Backcross to C57BL/6 (Heterozygote x C57BL/6JJmsSlc)
Health Report
Gene Details
Promoter No Data
1 Symbol Ptn
Symbol name pleiotrophin
Chromosome 6
Common name HB-GAM, HBGF-8, heparin-binding growth factor 8, heparin-binding growth-associated molecule, Osf-1, Osf1
Symbol description No Data
Promoter polyoma virus thymidine kinase gene promoter (tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 6
Common name neo; neomycin;
Symbol description No Data
References Genes Cells. 2006 Dec;11(12):1405-17.


Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors.
Research applications Cancer Research,
Cell Biology Research,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Muramatsu, Hisako (aichi-gakuin University) Muramatsu, Hisako
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months