RBRC02428, B6.Cg-Kras<tm1Mok> Trp53<tm2Mok> Tg(hKrasPAC)1Mok

RBRC No. RBRC02428
Type Targeted Mutation and TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Kras<tm1Mok> Trp53<tm2Mok> Tg(hKrasPAC)1Mok
Former Common name mouse K-ras, p53 KO, K-ras(PAC)Tg, B6-Kras KO/p53 KO/KrasPAC Tg
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Triple mutant mice having a Kras gene knockout, p53 (Trp53) knockout (lacZ reporter) and human KRAS transgenene.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 11
Common name neo; neomycin;
Symbol description No Data
2 Symbol Trp53
Symbol name transformation related protein 53
Chromosome 11
Common name p53
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome 11
Common name No Data
Symbol description E. coli beta galactosidase
4 Symbol Kras
Symbol name v-Ki-ras2 Kirsten rat sacroma viral oncogene homolog
Chromosome 6
Common name K-ras, Ki-ras, Kras-2, Kras2
Symbol description No Data
5 Symbol KRAS
Symbol name v-Ki-ras2 Kirsten rat sacroma viral oncogene homolog (human)
Chromosome UN
Common name K-ras, Ki-ras, Kras-2, Kras2
Symbol description No Data
References Biochem Biophys Res Commun. 1994 Jul 29;202(2):830-7.
Oncogene. 1997 Sep 4;15(10):1151-9.

Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
Research applications Cancer Research,
Cell Biology Research,
Immunology and Inflammation Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 15, 1151-1159 (1997). Biochem. Biophys. Res. Commun., 202, 830-837 (1994).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months