RBRC02432, (hRN8-12 x hAG2-5)F1

RBRC No. RBRC02432
Type TransgeneCartagena
Species Mus musculus
Strain name (hRN8-12 x hAG2-5)F1
Former Common name No Data
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Akiyoshi Fukamizu, University of Tsukuba in 1991. C57BL/6 background.
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol AGT
Symbol name Angiotensinogen (human)
Chromosome UN
Common name No Data
Symbol description No Data
2 Symbol REN1
Symbol name renin 1 structural (human)
Chromosome UN
Common name No Data
Symbol description No Data
References Biochem Biophys Res Commun. 1989 Dec 15;165(2):826-32.
Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9.

Tissue-specific expression of the human renin gene in transgenic mice.
Tissue-specific expression of the human renin gene in transgenic mice.
Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Biochemical and Biophysical Research Communications, 165, 826-832 (1989).
Biochemical and Biophysical Research Communications, 180, 1103-1109 (1991).
Additional information
1 Mouse of the Month May 2012
Systolic blood pressure
2 Lab HP (Japanese)
3 Genotyping protocol <PCR>
Depositor Fukamizu, Akiyoshi (University of Tsukuba) Fukamizu, Akiyoshi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation. J Am Soc Nephrol. (2012).(22440899)
Kawarazaki W, Nagase M, Yoshida S, Takeuchi M, Ishizawa K, Ayuzawa N, Ueda K, Fujita T.
Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive mice. Biomed Rep.1(3): 359-364 (2013).(24648949)
Inui Y, Mochida H, Yamairi F, Okada M, Ishida J, Fukamizu A, Arakawa K.
Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure. PLoS ONE12(8): e0181055 (2017).(28800627)
Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro E, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A.