RBRC02477, B6;129-Grin2a<tm1Nak> Grin2b<tm1Stl> Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>

RBRC No. RBRC02477
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Grin2a<tm1Nak> Grin2b<tm1Stl> Drd2<tm1Mok> Drd3<tm1Mok> Drd4<tm1Mok>
Former Common name B6-NR2A/NR2B/D2R/D3R/D4R KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description NR2A (Grin2a), NR2B (Grin2b), D2R (Drd2), D3R (Drd3) and D4R (Drd4) genes multiple knockout mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Drd3
Symbol name dopamine receptor 3
Chromosome 16
Common name D3 receptor, D3R
Symbol description No Data
2 Symbol Grin2a
Symbol name glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Chromosome 16
Common name No Data
Symbol description No Data
3 Symbol Grin2b
Symbol name glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Chromosome 6
Common name GluRepsilon2, NMDAR2B, Nmdar2b, NR2B
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 6
Common name neo; neomycin;
Symbol description No Data
5 Symbol Drd4
Symbol name dopamine receptor 4
Chromosome 7
Common name D4R, Drd-4
Symbol description No Data
6 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 7
Common name No Data
Symbol description No Data
7 Symbol Drd2
Symbol name dopamine receptor D2
Chromosome 9
Common name D2 receptor, D2R, Drd-2
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
8 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name neo; neomycin;
Symbol description No Data
9 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name neo; neomycin;
Symbol description No Data
Promoter mouse RNA polymerase II large subunit promoter
10 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 7
Common name neo; neomycin;
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
11 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 16
Common name No Data
Symbol description No Data
References Genes Cells. 1996 Feb;1(2):253-68.
J Neurosci. 1996 Dec 15;16(24):7859-67.

Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Nerurosci., 16, 7859-7867 (1996).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Drs. Motoya Katsuki and Toshikuni Sasaoka is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months