| RBRC No. | RBRC02484 |
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|---|---|---|---|---|---|---|---|---|---|
| Type | Targeted Mutation and Transgene |
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| Species | Mus musculus | ||||||||
| Strain name | B6.Cg-B6.Cg-Hras1<tm1Mok> Nras<tm1Mok> Tg(HRAS/floxed)1Mok | ||||||||
| Former Common name | H-ras, N-ras double KO, L-Tg, B6-Hras KO/Nras KO/HRASfloxed Tg | ||||||||
| H-2 Haplotype | No Data | ||||||||
| ES cell line | CCE/EK.CCE [129S/SvEv-Gpi1 |
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| Background strain | No Data | ||||||||
| Appearance | |||||||||
| 1 | Appearance | No Data | |||||||
| Genotype | No Data | ||||||||
| Strain development | Developed by Motoya Katsuki, National Institutes of Natural Sciences. | ||||||||
| Strain description | Hras knockout, Nras knockout and Lras transgenic triple mutant mice. | ||||||||
| Health Report | No Data | ||||||||
| Gene Details | |||||||||
| Promoter | No Data | ||||||||
| 1 | Symbol | Nras | |||||||
| Symbol name | neuroblastoma ras oncogene | ||||||||
| Chromosome | 3 | ||||||||
| Common name | N-ras | ||||||||
| Symbol description | No Data | ||||||||
| 2 | Symbol | Csde1 | |||||||
| Symbol name | cold shock domain containing E1, RNA binding | ||||||||
| Chromosome | 3 | ||||||||
| Common name | No Data | ||||||||
| Symbol description | No Data | ||||||||
| 3 | Symbol | Hras | |||||||
| Symbol name | Harvey rat sarcoma virus oncogene | ||||||||
| Chromosome | 7 | ||||||||
| Common name | c-H-ras, c-rasHa, H-ras, Ha-ras, Harvey-ras, Hras-1, ras | ||||||||
| Symbol description | No Data | ||||||||
| 4 | Symbol | neo | |||||||
| Symbol name | No Data | ||||||||
| Chromosome | 7 | ||||||||
| Common name | No Data | ||||||||
| Symbol description | No Data | ||||||||
| Promoter | herpes simplex virus thymidine kinase promoter (HSV tk promoter) | ||||||||
| 5 | Symbol | neo | |||||||
| Symbol name | neomycin resistance gene (E. coli) | ||||||||
| Chromosome | 3 | ||||||||
| Common name | neo; neomycin; | ||||||||
| Symbol description | No Data | ||||||||
| References | Oncogene. 2000 Jun 15;19(26):2951-6. Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. |
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| Research applications | No Data | ||||||||
| Specific Term and Conditions | The following terms and conditions will be requested by the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncogene, 19, 2951-2956 (2000). EMBO J., 21, 1021-1030 (2000). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
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| Additional information | |||||||||
| 1 | No Data | ||||||||
| Depositor | Sasaoka, Toshikuni (Niigata university)  |
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| Strain Status / Availability (Expected delivery) |
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