RBRC02485, B6.Cg-Hras1<tm1Mok> Nras<tm1Mok> Kras<tm1Mok> Tg(HRAS/floxed)1Mok

RBRC No. RBRC02485
Type Targeted Mutation and TransgeneCartagena
Species Mus musculus
Strain name B6.Cg-Hras1<tm1Mok> Nras<tm1Mok> Kras<tm1Mok> Tg(HRAS/floxed)1Mok
Former Common name H-ras, N-ras, K-ras triple KO, L-Tg, B6-Hras KO/Nras KO/Kras KO/HRASfloxed Tg
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Hras knockout, Nras knockout, Kras knockout and Lras transgenic multiple mutant mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Nras
Symbol name neuroblastoma ras oncogene
Chromosome 3
Common name No Data
Symbol description No Data
2 Symbol Csde1
Symbol name cold shock domain containing E1, RNA binding
Chromosome 3
Common name No Data
Symbol description No Data
3 Symbol Kras
Symbol name v-Ki-ras2 Kirsten rat sarcome viral oncogene homolog
Chromosome 6
Common name No Data
Symbol description No Data
4 Symbol Hras
Symbol name Harvey rat sarcoma virus oncogene
Chromosome 7
Common name No Data
Symbol description No Data
5 Symbol neo
Symbol name No Data
Chromosome 7
Common name No Data
Symbol description No Data
6 Symbol HRAS
Symbol name Harvey rat sarcoma virus oncogene (human)
Chromosome UN
Common name No Data
Symbol description No Data
7 Symbol loxP
Symbol name phage P1 loxP
Chromosome UN
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
8 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 3
Common name neo; neomycin;
Symbol description No Data
References Oncogene. 1997 Sep 4;15(10):1151-9.
Oncogene. 2000 Jun 15;19(26):2951-6.

K-ras is essential for the development of the mouse embryo.
K-ras is essential for the development of the mouse embryo.
K-ras is essential for the development of the mouse embryo.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 19, 2951-2956 (2000). EMBO J., 21, 1021-1030 (2000). Oncogene, 15, 1151-1159 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months