RBRC02573, B6.129-Traf5<tm1Hna>

RBRC No. RBRC02573
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129-Traf5<tm1Hna>
Former Common name B6.traf5<-/->, TRAF5 KO,C57BL/6
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Drs. Hiroshi Nakano and Haruhio Koseki in 1999.
Strain description Homozygous mutant mice show defects in lymphocyte activation.
Colony maintenance Sibling Mating (Homozygote x Homozygote)
Homozygous mutant mice are viable and fertile.
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
May 10, 2010 2-検 E
Mar 8, 2010 2-検 E
Jan 12, 2010 2-検 E
Nov 9, 2009 2-検 E
Sep 7, 2009 2-検 E
Jul 6, 2009 2-検 E
May 12, 2009 2-検 E
May 11, 2009 2-検 E

Gene Details
Promoter No Data
1 Symbol Traf5
Symbol name Tnf receptor-associated factor 5
Chromosome 1
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 1
Common name neo; neomycin;
Symbol description No Data
References J Immunol. 2004 Apr 1;172(7):4292-7.

TNF receptor-associated factor 5 limits the induction of Th2 immune responses.
TNF receptor-associated factor 5 limits the induction of Th2 immune responses.
TNF receptor-associated factor 5 limits the induction of Th2 immune responses.
Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
The recipient of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Nakano, Hiroyasu (Juntendo University) Nakano, Hiroyasu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Tumor Necrosis Factor Receptor Associated Factor 5 is an Essential Mediator of Ischemic Brain Infarction. J Neurochem. (2013).(23413803)
Wang L, Lu Y, Guan H, Jiang D, Guan Y, Zhang X, Nakano H, Zhou Y, Zhang Y, Yang L, Li H.