RBRC02686, B6.Cg-Tnxb<tm1Kmat>

RBRC No. RBRC02686
Type Targeted Mutation CongenicCartagena wks
Species Mus musculus
Strain name B6.Cg-Tnxb<tm1Kmat>
Former Common name Tnx-/-(F10), TNX-/- F10
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain C57BL/6NCrSlc
Appearance
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Kenichi Matsumoto, Hokkaido University in 2001. This strain was backcrossed to C57BL/6 over 10 times.
Strain description Tnxb, tenascin XB knock-out mice. This strain is useful to study the biological function of extracellular matrix tenascin-X in vivo. TNX-/- F10 line.
Colony maintenance Heterozygote x Wild-type [C57BL/6CrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Tnxb
Symbol name tenascin XB
Chromosome 17
Common name Tnx
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 17
Common name neo; neomycin;
Symbol description No Data
References Genes Cells 2001 Dec;6(12):1101-11.
Genes Cells 2004 Aug;9(8):737-48.

Tumour invasion and metastasis are promoted in mice deficient in tenascin-X.
Tumour invasion and metastasis are promoted in mice deficient in tenascin-X.
Tumour invasion and metastasis are promoted in mice deficient in tenascin-X.
Research applications Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genes Cells, 6, 1101-1111 (2001).
The RECIPIENT must contact the DEPOSITOR in the case of application for any publications, patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP (Japanese)
2 Genotyping protocol <PCR>
Depositor Matsumoto, Kenichi (Shimane University)
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months