RBRC02692, B6.129X1-Lilrb4a<tm1Ttk>

RBRC No. RBRC02692
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6.129X1-Lilrb4a<tm1Ttk>
Former Common name gp49B
H-2 Haplotype No Data
ES cell line RW4 [129X1/SvJ]
Background strain C57BL/6NCrlCrlj
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Dr. Toshiyuki Takai, Tohoku University in 2008.
Strain description Lilrb4 knock-out mice. Lilrb4 (gp49B) is a member of the immunoglobulin superfamily, containing immunoreceptor tyrosine-based inhibitory motifs that can deliver an inhibitor signal in mast and NK cells.
Colony maintenance Sibling x Sibling (Homozygote x Homozygote)
Homozygous mice are viable and fertile.
Health Report
BRC facility Health Report in the last year and a half

Examination Date Room Rack
Jul 10, 2017 2-検 G
May 15, 2017 2-検 G
Mar 13, 2017 2-検 G
Jan 16, 2017 2-検 G
Nov 14, 2016 2-検 G
Sep 12, 2016 2-検 G
Jul 11, 2016 2-検 G
May 16, 2016 2-検 G

Gene Details
Promoter No Data
1 Symbol Lilrb4a
Symbol name leukocyte immunoglobulin-like receport, subfamily B, member 4
Chromosome 10
Common name CD85K, Gp49b, HM18, ILT3, Lilrb4
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 10
Common name neo; neomycin;
Symbol description No Data

Research applications Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 273, 1070-1074 (1998). J. Immunol., 165, 4970-4977 (2000).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Takai, Toshiyuki (Tohoku University) Takai, Toshiyuki
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
Decidual Macrophage Functional Polarization during Abnormal Pregnancy due to Toxoplasma gondii: Role for LILRB4. Front Immunol8: 1013 (2017).(28883820)
Li Z, Zhao M, Li T, Zheng J, Liu X, Jiang Y, Zhang H, Hu X.