RBRC02781, B6.Cg-Cd8a<a> Tg(Tcra2C,Tcrb2C)1Dlo

RBRC No. RBRC02781
Type Transgene CongenicCartagena
Species Mus musculus
Strain name B6.Cg-Cd8a<a> Tg(Tcra2C,Tcrb2C)1Dlo
Former Common name 2C TCR, B6-Cd8a 2CTCR Tg
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development The transgene was developed by Dennis Loh, Washington University School of Medicine in 1988. The mice were deposited by Takanori Teshima, Kyushu University Hospital, through Paul Martin, Fred Hutchinson Cancer Research Center. H-2b and Ly2.1 (Cd8.1) background.
Strain description 2C TCR transgenic mice expressing the alpha beta antigen receptor from the cytotoxic T-lymphocyte clone 2C. Ly2.1 (Cd8.1) congenic line.
Colony maintenance Tg : Carrier x Noncarrier ; Ly2 : Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol Cd8a
Symbol name CD8 antigen, alpha chain
Chromosome 6
Common name No Data
Symbol description No Data
2 Symbol Tcra2C
Symbol name T cell receptor alpha chain
Chromosome UN
Common name No Data
Symbol description No Data
3 Symbol Tcrb2C
Symbol name T cell receptor beta chain
Chromosome UN
Common name No Data
Symbol description No Data
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome UN
Common name No Data
Symbol description No Data
References Nature. 1988 Sep 15;335(6187):271-4.

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.
Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.
Research applications Immunology and Inflammation Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Teshima, Takanori (Kyushu university hospital) Teshima, Takanori
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months