RBRC03163, B6J.129P2-Hmox1<tm1Mym>

RBRC No. RBRC03163
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6J.129P2-Hmox1<tm1Mym>
Former Common name HO-1 floxed mouse
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain C57BL/6JJmsSlc
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Masayuki Yamamoto, Center for Tsukuba Advanced Research Alliance, Tsukuba University in 2001. E14 ES cells were used. The mutant mice were backcrossed to C57BL/6 (C57BL/6JJcl and C57BL/6JJmsSlc).
Strain description Hmox1 gene floxed mice. Exon 3 to 5 was flanked by loxP sites.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJmsSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Hmox1
Symbol name heme oxygenase (decycling) 1
Chromosome 8
Common name No Data
Symbol description No Data
2 Symbol DsRed2
Symbol name Red Fluorescent Protein (Discosoma sp.)
Chromosome 8
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 8
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome 8
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Tohoku J. Exp. Med., 216, 331-339 (2008 ).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The DEPOSITOR should be a co-author in articles when the users publish their data using these mice for TWO years after provided to the RIKEN BRC. Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
Additional information
1 Lab HP (Japanese)
2 Genetic Background
3 Genotyping protocol <PCR>
Depositor Yamamoto, Masayuki (Tohoku university) Yamamoto, Masayuki
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
The microglial alpha 7 acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing HO-1 via Nrf2. Antioxid Redox Signal. (2013).(23311871)
Parada E, Egea J, Buendia I, Negredo P, Cunha AC, Cardoso S, Soares MP, Lopez MG.
Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J. Clin. Invest. (2015).(26011640)
Schallner N, Pandit R, LeBlanc R 3rd, Thomas AJ, Ogilvy CS, Zuckerbraun BS, Gallo D, Otterbein LE, Hanafy KA.
Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. Mol. Nutr. Food Res. (2015).(26047311)
Parada E, Buendia I, Navarro E, Avendañ C, Egea J, Lóez MG.