RBRC03438, B6;129P2-Arx<tm1Kki>/6Rbrc

RBRC No. RBRC03438
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Arx<tm1Kki>/6Rbrc
Former Common name Arx-6 KO
H-2 Haplotype No Data
ES cell line E14TG2a [129P2/OlaHsd]carries Hprt
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kunio Kitamura, Mitsubishi Kagaku Institute of Life Sciences. E14 ES cells were used to generate the mutant mice.
Strain description Arx gene knockout mice. A lacZ-neo cassette was inserted into the exon 2 of Arx gene. Hemizygous (-/Y) mutant males die within 12 hrs after birth. Main line: Arx-6 KO (RBRC03438).
Colony maintenance Heterozygote (female) x Wild-type (male)[C57BL/6JJcl]
Health Report No Data
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 PolyA signal
Chromosome X
Common name No Data
Symbol description No Data
2 Symbol Arx
Symbol name aristaless related homeobox
Chromosome X
Common name No Data
Symbol description No Data
3 Symbol IRES
Symbol name internal ribosomal entry site (EMCV)
Chromosome X
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome X
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome X
Common name No Data
Symbol description No Data
References Nat Genet 2002 Nov;32(3):359-69. Epub 2002 Oct 15.

Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.
Research applications Fluorescent Proteins/lacZ System,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The BIOLOGICAL RESOURCE shall be used only for academic research purposes by
a non-profit organization.
The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and
negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL
RESOURCE for purposes of other than academic research.
In publishing the research results to be obtained by use of the BIOLOGICAL
RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the
source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi
Chemical Corporation.
The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical
Corporation of RECIPIENT organization, RECIPIENT name, the specific research
purpose and the date of distribution.
Additional information
1 No Data
Depositor Kitamura, Kunio (Mitsubishi Chemical Corporation) Kitamura, Kunio
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months