RBRC03654, B6;129-Arx<tm(GCG)Kki>/7-1Rbrc

RBRC No. RBRC03654
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Arx<tm(GCG)Kki>/7-1Rbrc
Former Common name Arx (GCG)7-1 KI (B6)
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kunio Kitamura, Mitsubishi Kagaku Institute of Life Sciences. CCE/EK.CCE ES cells were used to generate the mutant mice.
Strain description Arx GCG 7 repeats knock-in mice. 7 repeats of the GCG triple were inserted at the codon 330 of Arx gene. C57BL/6 mixed background (RBRC03654 and RBRC03656), 129 background (RBRC03655), C3H mixed background (RBRC03657), ICR mixed background (RBRC03665).
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 polyA signal
Chromosome X
Common name No Data
Symbol description No Data
2 Symbol Arx
Symbol name aristaless related homeobox
Chromosome X
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome X
Common name No Data
Symbol description No Data
References

Research applications Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The BIOLOGICAL RESOURCE shall be used only for academic research purposes by
a non-profit organization.
The RECIPIENT of a non-profit organization must prior contact RIKEN BRC and
negotiate with Mitsubishi Chemical Corporation to use the BIOLOGICAL
RESOURCE for purposes of other than academic research.
In publishing the research results to be obtained by use of the BIOLOGICAL
RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate the
source of the BIOLOGICAL RESOURCE and an acknowledgment to Mitsubishi
Chemical Corporation.
The RECIPIENT agrees that RIKEN BRC informs annually to Mitsubishi Chemical
Corporation of RECIPIENT organization, RECIPIENT name, the specific research
purpose and the date of distribution.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Kitamura, Kunio (Mitsubishi Chemical Corporation) Kitamura, Kunio
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
An Epilepsy-Related ARX Polyalanine Expansion Modifies Glutamatergic Neurons Excitability and Morphology Without Affecting GABAergic Neurons Development. Cereb Cortex. (2012).(22628459)
Beguin S, Cr pel V, Aniksztejn L, Becq H, Pelosi B, Pallesi-Pocachard E, Bouamrane L, Pasqualetti M, Kitamura K, Cardoso C, Represa A.
Aristaless-Related Homeobox Plays a Key Role in Hyperplasia of the Pancreas Islet alpha-Like Cells in Mice Deficient in Proglucagon-Derived Peptides. PLoS One.8(5): e64415 (2013).(23671715)
Xu S, Hayashi Y, Takagishi Y, Itoh M, Murata Y.
Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation. Hum Mol Genet. (2013).(24122442)
Lee K, Mattiske T, Kitamura K, Gecz J, Shoubridge C.