RBRC04021, B6.129-Dnase2a<tm1Osa> Ifnar1<tm1Agt>

RBRC No. RBRC04021
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Dnase2a<tm1Osa> Ifnar1<tm1Agt>
Former Common name DNaseII / IFN-IR double knock out
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain C57BL/6
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kohki Kawane and Shigekazu Nagata, Graduate School of Medicine, Kyoto University in 2004. C57BL/6 background (over N8 generations).
Strain description DNaseII/IFN-IR double knockout mice. Double homozygous mutant mice develop polyarthritis as age.
Colony maintenance Dnase2a: Heterozygote x Wild-type; Ifnar1: Homozygote x Homozygote
Health Report
Gene Details
Promoter No Data
1 Symbol Ifnar1
Symbol name interferon (alpha and beta) receptor 1
Chromosome 16
Common name No Data
Symbol description No Data
2 Symbol Dnase2a
Symbol name deoxyribonuclease II alpha
Chromosome 8
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 8
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 8
Common name No Data
Symbol description No Data
References Nat Immunol. 2005 Jan;6(1):49-56. Epub 2004 Nov 28.
Nature. 2006 Oct 26;443(7114):998-1002.

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA.
Research applications Cre/loxP system,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature, 443, 998-1002 (2006). Nat. Immunol., 6, 49-56 (2005).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose. The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP
2 Mouse of the Month Aug 2012
3 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Osaka University)
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :