RBRC04395, B6;129-Siglec1<tm1(HBEGF)Mtka>

RBRC No. RBRC04395
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129-Siglec1<tm1(HBEGF)Mtka>
Former Common name CD169-DTR KO
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunology. R1 ES cells were used. C57BL/6 background.
Strain description CD169 (Siglec1) DTR knock-in mice. HB-EGF is expressed from CD169 locus.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Siglec1
Symbol name sialic acid binding Ig-like lectin 1, sialoadhesin
Chromosome 2
Common name No Data
Symbol description No Data
2 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome 2
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 2
Common name No Data
Symbol description No Data
References J Clin Invest. 2007 Aug 1;117(8):2268-2278.

Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens.
Research applications Cre/loxP system,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Biotechnol., 19, 746-750 (2001). J. Clin Invest., 117, 2268-2278 (2007).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Kenji Kohno, Ph.D. and Masato Tanaka, Ph.D. The recipient shall obtain a prior written approval from the depositor.
Additional information
1 Mouse of the Month Dec 2012
Genetic Background
2 Genotyping protocol <PCR>
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live
Live mouse :
BRC mice in Publications
Title Journal
(PMID)
Author
Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22. Inflammation40(4): 1191-1203 (2017).(28466432)
Wang D, Li Q, Yang Y, Hao S, Han X, Song J, Yin Y, Li X, Tanaka M, Qiu CH.
G-CSF mediates lung injury in mice with adenine-induced acute kidney injury. Int. Immunopharmacol.63: 1-8. (2018).(30056257)
Jing W, Qin F, Guo X, Sun Y, Yan C, Qiu C, Tanaka M, Shi B, Zhao Y.