Strain Information | |
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Image | |
BRC No. | RBRC04434 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.129-Msi1<tm1Okn> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Shinsuke Shibata and Hideyuki Okano, Keio University School of Medicine. |
Strain description | C57BL/6J background Msi1 deficient mice (RBRC04434) frequently died of obstructive hydrocephalus within a couple of month with aberrant cell proliferation around cerebral aqueduct. Both male and female are infertile because of the early death of hydrocephalus. On the other hand, CD-1 (ICR) background Msi1 deficient mice (RBRC04435) survive to adult without gross anatomical phenotype. Since both male and female are fertile, it is possible to mate between Msi1 null mice. |
Colony maintenance | |
References | Proc. Natl. Acad. Sci. USA, 99, 15194-15199 (2002). 12407178 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)5neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) |
Ordering Information | |
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Donor DNA | mouse Musashi1 genomic DNA, E. coli Tn5neo gene, mouse PGK promoter, SV40 polyA |
Research application | Cell Biology Research |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 99, 15194-15199 (2002).For use of the BIOLOGICAL RESOURCE, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. |
Depositor | Hideyuki Okano (Keio University) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |