RBRC04489, B6.B6CB-Hoil1<tm1Kiwa>

RBRC No. RBRC04489
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.B6CB-Hoil1<tm1Kiwa>
Former Common name HOIL-1L KO
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Kazuhiro Iwai, Graduate School of Medicine, Osaka City University in 2004. TT2 ES cells were used to generate the mutant mice. The mice were backcrossed to C57BL/6.
Strain description Rbck1 (HOIL-1L) knockout mice. Homozygous mutant mice show attenuated TNF-alpha mediated NF-kappaB activation.
Colony maintenance Heterozygote x Homozygote [or Crossing to C57BL/6JJmsSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Rbck1
Symbol name RanBP-type and C3HC4-type zinc finger containing 1
Chromosome 2
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name No Data
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nat. Cell. Biol., 11, 123-132 (2009).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Iwai, Kazuhiro (Kyoto University) Iwai, Kazuhiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months