Strain Information | |
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Image | |
BRC No. | RBRC04489 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6.B6CB-Hoil1<tm1Kiwa> |
Former Common name | HOIL-1L KO |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Kazuhiro Iwai, Graduate School of Medicine, Osaka City University in 2004. TT2 ES cells were used to generate the mutant mice. The mice were backcrossed to C57BL/6. |
Strain description | Rbck1 (HOIL-1L) knockout mice. Homozygous mutant mice show attenuated TNF-alpha mediated NF-kappaB activation. |
Colony maintenance | Heterozygote x Homozygote [or Crossing to C57BL/6JJmsSlc] |
References | Nat. Cell. Biol., 11, 123-132 (2009). 19136968 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Rbck1RanBP-type and C3HC4-type zinc finger containing 12Rbck1<tm1Kiwa>Targeted mutation 1, Kazuhiro Iwai Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)2herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Ordering Information | |
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Donor DNA | herpes simplex virus thymidine kinase promoter (HSV tk promoter), E.coli Neomycin resistance gene, mouse Rbck1 genomic DNA |
Research application | |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Cell. Biol., 11, 123-132 (2009). The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Kazuhiro Iwai (Kyoto University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |