RBRC04802, B6.Cg-Bmper<tm1Ysas>/Rbrc

RBRC No. RBRC04802
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.Cg-Bmper<tm1Ysas>/Rbrc
Former Common name Cv2(tau-lacZ) (Acc.No.CDB0402K)
H-2 Haplotype No Data
ES cell line TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Dr. Yoshiki Sasai, Center for Developmental Biology, RIKEN.
Strain description This transgene contains tau-lacZ with a floxed neo in the first exon of Cv2 to replace with lacZ at the first ATG. Cv2 (Bmper : BMP-binding endothelial regulator) is essential for multiple organogenetic processes that involve Bmp signals. Cv2 homozygous mutant mice show effects in the vertebral column and eyes.
Colony maintenance Heterozygote x Wild-type [C57BL/6] Homozygous mutant mice are neonatal lethal.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Bmper
Symbol name BMP-binding endothelial regulator
Chromosome 9
Common name No Data
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome No Data
Common name neo; neomycin;
Symbol description No Data
3 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome No Data
Common name No Data
Symbol description No Data
4 Symbol loxP
Symbol name phage P1 loxP
Chromosome No Data
Common name No Data
Symbol description No Data
5 Symbol poly A
Symbol name poly A
Chromosome No Data
Common name No Data
Symbol description No Data
6 Symbol tau
Symbol name bovine tau protein cDNA
Chromosome No Data
Common name No Data
Symbol description No Data
References Development. 2006 Nov;133(22):4463-73. Epub 2006 Oct 11.

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
Research applications Cre/loxP system,
Fluorescent Proteins/lacZ System
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
1) The RECIPIENT shall obtain a prior agreement from Dr. Yoshiki Sasai (yoshikisasai@cdb.riken.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0402K, and Web Site (http:www.cdb.riken.jp/arg/mutant%20mice%20list.html) and the BIOLOGICAL RESOURCE is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Development, 133, 4463-4473 (2006).) (4) Please inform the DEPOSITOR (mutant@cdb.riken.jp) about the paper when published.
Additional information
1 No Data
Depositor RIKEN, CDB (RIKEN Center for Developmental Biology) RIKEN, CDB
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months