RBRC04834, C57BL/6J-Slc7a11<m1Mtka>

RBRC No. RBRC04834
Type Chemically-induced Mutation
Species Mus musculus
Strain name C57BL/6J-Slc7a11<m1Mtka>
Former Common name xCT mutant
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunologuy in 2005. Generated by RIKEN ENU mutagenesis project.
Strain description Slc7a11 mutant mice generated by ENU mutagenesis. A transverstion of G to T in exon 10 was caused and results in a premature termination at position 383 glycine. Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
Colony maintenance Heterozygote X Wild-type [C57BL/6JJcl] Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Slc7a11
Symbol name solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Chromosome 3
Common name xCTmu
Symbol description No Data
References

Research applications Cancer Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Matl. Acad. Sci., USA, 107, 6436-6441(2010).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
A RECIPIENT shall obtain a prior written approval from the DEPOSITOR using approval form.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Tanaka, Masato (RIKEN Research Center For Allergy and Immunology) Tanaka, Masato
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months