|Former Common name||xCT mutant|
|H-2 Haplotype||No Data|
|Strain development||Developed by Masato Tanaka, RIKEN Research Center for Allergy and Immunologuy in 2005. Generated by RIKEN ENU mutagenesis project.|
|Strain description||Slc7a11 mutant mice generated by ENU mutagenesis. A transverstion of G to T in exon 10 was caused and results in a premature termination at position 383 glycine. Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.|
|Colony maintenance||Heterozygote X Wild-type [C57BL/6JJcl] Homozygous mutant mice exhibit decreased survival of LPS-induced macropgages and increase chemically-induced tumors.|
|Health Report||No Data|
|Symbol name||solute carrier family 7 (cationic amino acid transporter, y+ system), member 11|
|Symbol description||No Data|
|Research applications||Cancer Research,
Immunology and Inflammation Research
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Proc. Matl. Acad. Sci., USA, 107, 6436-6441(2010).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
A RECIPIENT shall obtain a prior written approval from the DEPOSITOR using approval form.
|2||Genotyping protocol <PCR>|
|Depositor||Tanaka, Masato (RIKEN Research Center For Allergy and Immunology)|
|Strain Status /