RBRC04937, B6;129S4-Atrx<tm1Enl>

RBRC No. RBRC04937
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S4-Atrx<tm1Enl>
Former Common name B6-Atrx KO (ATRX)
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hideyuki Beppu and En Li, Massachusetts General Hospital, Harvard Medical School.
Strain description No Data
Colony maintenance Heterozygote (female), Hemizygote (male) x Wild-type [C57BL/6JJmsSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol IRES
Symbol name internal ribosomal entry site (EMCV)
Chromosome X
Common name internal ribosomal entry site from EMCV
Symbol description No Data
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome X
Common name neo; neomycin;
Symbol description No Data
3 Symbol Atrx
Symbol name alpha thalassemia/mental retardation syndrome X-linked homolog (human); targeted mutation 1, En Li
Chromosome X
Common name No Data
Symbol description No Data
4 Symbol lacZ
Symbol name beta-galactosidase (E. coli)
Chromosome X
Common name No Data
Symbol description E. coli beta galactosidase
References

Research applications Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. Hippocampus. 2011 21(6):678-87. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and Massachusetts General Hospital (Boston, USA) and must obtain a prior written consent from the DEPOSITOR and Massachusetts Genearal Hospital.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Beppu, Hideyuki (UNIVERSITY OF TOYAMA) Beppu, Hideyuki
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
(PMID)
Author
Targeting G-quadruplex DNA as Cognitive Function Therapy for ATR-X Syndrome. Nat. Med. (2018).(29785027)
Shioda N, Yabuki Y, Yamaguchi K, Onozato M, Li Y, Kurosawa K, Tanabe H, Okamoto N, Era T, Sugiyama H, Wada T, Fukunaga K.