RBRC04950, B6;129P2-Traf6<tm1Jino>

RBRC No. RBRC04950
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129P2-Traf6<tm1Jino>
Former Common name B6-Traf6 KO
H-2 Haplotype No Data
ES cell line E14.1 [129P2/OlaHsd]
Background strain No Data
1 Appearance No Data
Genotype No Data
Strain development A 2.5 kb genomic fragement was replaced with a neomycin selection cassette. The mutant mice were crossed with C57BL/6.
Strain description Traf6 knockout mice. A 2.5 kb genomic fragment was replaced with a neomycin selection cassette. Homozygous mutant mice exhibit severe osteopetrosis and abnormal immune cell development and function, and die within around 2 weeks after birth. Homozygous mice represented only 12% of offspring. C57BL/6 background (RBRC04950), BALB/c background (RBRC05386).
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Traf6
Symbol name TNF receptor-associated factor 6; targeted mutation 1, Jun-ichiro Inoue
Chromosome 2
Common name No Data
Symbol description No Data
Promoter mouse Polr2a promoter
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 2
Common name neo; neomycin;
Symbol description No Data

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
1. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
2. RECIPIENT must contact the DEPOSITOR in the case of application for any patents,any manuscripts, any public presentation,or commercial use, based on the results from the use of the BIOLOGICAL RESOURCE.
3. RECIPIENT must not yield the BIOLOGICAL RESOURCE to other parties or persons.
Additional information
1 Mouse of the Month Sep 2012
2 Genotyping protocol <PCR>
Depositor Inoue, Jyunichirou (The Institute of Medical Science, The University of Tokyo) Inoue, Jyunichirou
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
Rapid Activation of Transforming Growth Factor beta-Activated Kinase 1 in Chondrocytes by Phosphorylation and K(63) -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. 69(3): 565-575 (2016).(27768832)
Ismail HM, Didangelos A, Vincent TL, Saklatvala J.