|Former Common name||B6-Th-ALK/F1174L Tg#5L|
|H-2 Haplotype||No Data|
|Background strain||No Data|
|Strain development||Developed by Hiroaki Honda, Research Institute for Radiation Biology and Medicine and Junko Takita, The University of Tokyo Hospital. A F1174L mutant hALK gene under the TH promoter was injected into the pronuclei of C57BL/6N fertilized eggs.|
|Strain description||Human ALK (anaplastic lymphoma kinase) gene having F1174L mutation transgenic mice. F1174L mutation was identified in a patient with an inflammatory myofibroblastic tumor harboring a RANBP2-ALK translocation.|
|Promoter||human tyrosine hydroxylase promoter|
|Symbol name||human ALK cDNA (F1174L mutant)|
|Common name||No Data|
|Symbol description||No Data|
|References||Nature. 2008 Oct 16;455(7215):971-4.
Oncogenic mutations of ALK kinase in neuroblastoma.
|Research applications||Cancer Research,
Mouse Models for Human Disease
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
|2||Genotyping protocol <PCR>|
|Depositor||Honda, Hiroaki (Tokyo Women’s Medical University)|
|Strain Status /