RBRC05203, C57BL/6-Tg(TH-ALK*F1174L)5Homy

RBRC No. RBRC05203
Type TransgeneCartagena
Species Mus musculus
Strain name C57BL/6-Tg(TH-ALK*F1174L)5Homy
Former Common name B6-Th-ALK/F1174L Tg#5L
H-2 Haplotype No Data
Background strain No Data
1 Appearance No Data
Genotype No Data
Strain development Developed by Hiroaki Honda, Research Institute for Radiation Biology and Medicine and Junko Takita, The University of Tokyo Hospital. A F1174L mutant hALK gene under the TH promoter was injected into the pronuclei of C57BL/6N fertilized eggs.
Strain description Human ALK (anaplastic lymphoma kinase) gene having F1174L mutation transgenic mice. F1174L mutation was identified in a patient with an inflammatory myofibroblastic tumor harboring a RANBP2-ALK translocation.
Health Report
Gene Details
Promoter human tyrosine hydroxylase promoter
1 Symbol ALK
Symbol name human ALK cDNA (F1174L mutant)
Chromosome UN
Common name No Data
Symbol description No Data
References Nature. 2008 Oct 16;455(7215):971-4.

Oncogenic mutations of ALK kinase in neuroblastoma.
Research applications Cancer Research,
Mouse Models for Human Disease
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Honda, Hiroaki (Tokyo Women’s Medical University) Honda, Hiroaki
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months