RBRC05236, B6.129-Col19a1<tm1Rmz>

RBRC No. RBRC05236
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Col19a1<tm1Rmz>
Former Common name B6-Col19a1 KO
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Hideaki Sumiyoshi (Oita Medical University), Francesco Ramirez (Weill College of Medical of Cornell University) and Hidekatsu Yoshioka (Oita Medical University).
Strain description Coll9a1 knockout mice. IRES-lacZ and PGK-neo cassette replaced exon 4 of Col19a1. Homozygous mutant mice show eating disorder by impaired sphincter relaxation in the lower esophagus, and more than 90% (in 129), 30-50% (in C57BL/6) of the mice die within 3 weeks after birth. Esophagus achalasia is also observed with aging.
Colony maintenance Heterozygote x Wild-type
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Col19a1
Symbol name collagen, type XIX, alpha 1
Chromosome 1
Common name No Data
Symbol description No Data
References J Cell Biol 2004 Aug 16;166(4):591-600. Epub 2004 Aug 9.

Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
Additional information
1 No Data
Depositor Yoshioka, Hidekatsu (Oita university) Yoshioka, Hidekatsu
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months