RBRC05263, B6.DW-Tpst2<grt>/Hkv

RBRC No. RBRC05263
Type Spontaneous Mutation
Species Mus musculus
Strain name B6.DW-Tpst2<grt>/Hkv
Former Common name B6-grt
H-2 Haplotype No Data
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Nobuya Sasaki and Takashi Agui, Graduate School of Veterinary Medicine, Hokkaido University in 2010. Tpst2<grt> allele derived from DW/J-Tpst2<grt> was backcrossed to C57BL/6JJcl for 14 generations.
Strain description Tpst2<grt> B6 congenic strain. Homozygous mutant mice show a delayed pubertal growth and hypothyroidism. Homozygous females are infertile and males show markedly-decreased fertility.
Colony maintenance Heterozygote x Wild-type [C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Tpst2
Symbol name protein-tyrosine sulfotransferase 2
Chromosome 5
Common name No Data
Symbol description No Data
References J Vet Med Sci. 2008 Oct;70(10):1043-9.
Mol Endocrinol. 2007 Apr 24;.

Female infertility in grt mice is caused by thyroid hormone deficiency, not by insufficient TPST2 activity in the reproductive organs.
Female infertility in grt mice is caused by thyroid hormone deficiency, not by insufficient TPST2 activity in the reproductive organs.
Female infertility in grt mice is caused by thyroid hormone deficiency, not by insufficient TPST2 activity in the reproductive organs.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Agui, Takashi (Graduate School of Veterinary Medicine, Hokkaido University) Agui, Takashi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months