RBRC05290, B6.129P2-Dscam<tm1.1Kzy>/A151Kzy

RBRC No. RBRC05290
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Dscam<tm1.1Kzy>/A151Kzy
Former Common name B6-Dscam KO#A151
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Exon 1 was removed by crossing with CAG-cre (B6 background). The mice were backcrossed to C57BL/6 over 21 times.
Strain description Dscam knockout mice. Dscam, Down syndrome cell adhesion molecule is a gene of neural Ig superfamily mediates cell adhesion and axon outgrowth. Homozygous mutant mice of C57BL/6 genetic background die within 24 hours after birth due to central respiratory defects. In BALB/c mixed background, Homozygous mutant mice are viable and survive to adulthood.
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Dscam
Symbol name Down syndrome cell adhesion molecule
Chromosome 16
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 16
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Mouse Models for Human Disease,
Neurobiology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Amano et al., J. Neurosci., 29(9):2984-2996. 2009
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 Mouse of the Month Jan 2012
2 Genotyping protocol <PCR>
Depositor Yamakawa, Kazuhiro (RIKEN) Yamakawa, Kazuhiro
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months