RBRC05540, B6.129-Brd1<tm1Hko>

RBRC No. RBRC05540
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Brd1<tm1Hko>
Former Common name Brd1 KO, B6-Brd1 KO
H-2 Haplotype No Data
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Atsushi Iwama, Graduate School of Medicine, Chiba University and Akihiko Koseki, RIKEN Research Center for Allergy and Immunology in 2005. The mutant mice were backcrossed to C57BL/6N.
Strain description Brd1 gene knockout mice. Exon 2 of Brd1 gene was replaced with a floxed neo cassette. Homozygous mutant mice show abnormal embryonic development including erythropoiesis (anemia), growth retardation, open neural tube and abnormal lens morphology, and die between E12.5 and E14.5.
Colony maintenance Heterozygote x Wild-type [C57BL/6NCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Brd1
Symbol name bromodomain containing 1
Chromosome 15
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 15
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 15
Common name neo; neomycin;
Symbol description No Data
References

Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Blood, 118, 2443-2453 (2011).
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Iwama, Atsushi (Graduate School of Medical and Pharmaceutical Sciences, Chiba University) Iwama, Atsushi
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months