RBRC05649, B6.129S4-Plin5<tm1Tosu>/Rbrc

RBRC No. RBRC05649
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S4-Plin5<tm1Tosu>/Rbrc
Former Common name B6-Plin5 KO, B6.129S4-Plin5<tm1>
H-2 Haplotype No Data
ES cell line J1 [129S4/SvJae]
Background strain C57BL/6JJcl
Appearance
1 Appearance No Data
Genotype No Data
Strain description Plin5 perilipin 5 gene knockout mice. Exons 2 to 4 were replaced with a floxed PGK-neo cassette. In homozygous mutant mice, heart lipid droplets were absent and the activity of fatty acid oxidation was increased.
Health Report
Gene Details
Promoter No Data
1 Symbol GH
Symbol name Growth hormone polyA (Bovine)
Chromosome 17
Common name No Data
Symbol description No Data
2 Symbol Plin5
Symbol name perilipin 5
Chromosome 17
Common name No Data
Symbol description No Data
3 Symbol loxP
Symbol name phage P1 loxP
Chromosome 17
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
4 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 17
Common name neo; neomycin;
Symbol description No Data
References J Biol Chem. 2006 May 19;281(20):14232-40. Epub 2006 Mar 29.

MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha.
MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha.
MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha.
Research applications Cardiovascular Research,
Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 287, 23852-23863 (2012).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Osumi, Takashi (University of hyogo) Osumi, Takashi
Strain Status /
Availability
(Expected delivery)


Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months