Strain Information | |
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Image | |
BRC No. | RBRC05652 |
Type | Transgene |
Species | Mus musculus |
Strain name | B6.Cg-Tg(alpha-MHC/miR143/145)9 |
Former Common name | B6-aMHC/miR143/145 Tg#9 |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Takashi Iwamoto, College of Life and Health Sciences, Chubu University in 2010. The transgene was injected into the (C57BL/6 x BALB/c)F2 fertilized eggs. The mice were crossed to C57BL/6J over 5 generations. |
Strain description | Transgenic mice expressing miR-143 and miR-145 in cardiomyocytes. Their hearts generally show low %FS after 2 months old and become enlarged. |
Colony maintenance | Carrier x Noncarrier [C57BL/6J(Crlj)]Tg mice show a high incidence of sudden death after 2-3 months old. |
References | Nature, 460, 529-533 (2009). 19626115 Biochem. Biophys. Res. Commun., 372, 856-861 (2008). 18533106 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter miR143pri-miR-143 (human)UNmiR143rat alpha-myosine heavy chain promoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter miR145pri-miR-145 (human)UNmiR145 |
Ordering Information | |
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Donor DNA | Mouse Alpha-myosin heavy chain promoter, Homo sapiens pri-miR-143, Homo sapiens pri-miR-145, Homo sapiens Growth hormone polyA signal |
Research application | Cardiovascular Research covid19_progression |
Specific Term and Conditions | In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested (will be announced). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval form the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from use of the BIOLOGICAL RESOURCE. |
Depositor | Takashi Iwamoto (Chubu University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |