|Former Common name||Asgr1 KO|
|H-2 Haplotype||No Data|
|ES cell line||JH1 [129S7/SvEvBrd]|
|Background strain||No Data|
|Strain development||Developed by Shun Ishibashi, Faculty of Medicine, University of Tokyo in 2001. JH1 ES cells derived from 129S7/SvEvBrd were used for the generation of knockout mice. The mice were backcrossed to C57BL/6J for 8 generations by Laboratory of Cancer Biology and Molecular Immunology, University of Tokyo.|
|Strain description||Asgr1 knockout mice. The transcription initiation codon and the sequences encoding the transmembrane domain of Asgr1 gene were replaced with a pol2neo cassette. Homozygous mice show an impaired hepatic clearance of asialoglycoproteins.|
|Colony maintenance||Heterozygote x Wild-type [C57BL/6JJcl]|
BRC facility Health Report in the last year and a half
|Symbol name||asialoglycoprotein receptor 1|
|Common name||No Data|
|Symbol description||No Data|
|Research applications||Cell Biology Research,
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
J. Biol. Chem., 276, 12624-12628 (2001).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
|Depositor||Irimura, Tatsuro (The University of Tokyo)|
|Strain Status /