RBRC05808, B6.129P2-Aldh2<tm1Kaw>

RBRC No. RBRC05808
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Aldh2<tm1Kaw>
Former Common name Aldh2KO
H-2 Haplotype No Data
ES cell line E14 [129P2/OlaHsd]
Background strain C57BL/6JJcl
1 Appearance No Data
Genotype No Data
Strain development Developed by Kyoko Kitagawa and Toshihiro Kawamoto, University of Occupational and Environmental Health in 1998. E14 ES cells were used. The mutant mice were backcrossed to C57BL/6 over 7 times.
Strain description Aldh2 gene knockout mice. A termination codon and a neomycin selection cassette was inserted into exon 3 of Aldh2 gene.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl] Homozygous mutant mice are viable and fertile.
Health Report
Gene Details
Promoter No Data
1 Symbol No Data
Symbol name SV40 Poly A signal
Chromosome 5
Common name No Data
Symbol description No Data
2 Symbol Aldh2
Symbol name aldehyde dehydrogenase 2, mitochondrial
Chromosome 5
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name No Data
Symbol description No Data

Research applications Metabolism Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
Additional information
1 Lab HP
2 Genotyping protocol <PCR>
Depositor Nakayama, Keiichi (Medical institute of bioregulation, Kyushu University) Nakayama, Keiichi
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA4-Dependent CCN1 Secretion. J. Am. Heart Assoc.7: e009111. (2018).(30371213)
Sumei Cui, Li Xue, Feihong Yang, Shuai Dai, Ziqi Han, Kai Liu, Baoshan Liu, Qiuhuan Yuan, Zhaoqiang Cui, Yun Zhang, Feng Xu, Yuguo Chen.