RBRC06138, B6.129P2-Serpina12<tm1>

RBRC No. RBRC06138
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129P2-Serpina12<tm1>
Former Common name Vaspin KO, B6-Serpina12 KO, Vaspin-/-
H-2 Haplotype No Data
ES cell line BK4 [129P2/OlaHsd]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Jun Wada, Department of Medicine and Clinical Science, Okayama University and Yoichiro Iwakura, Institute of Medical Sciences, University of Tokyo in 2008. 129P2 derived ES cells were used. The mutant mice were backcrossed to C57BL/6 over 10 times.
Strain description Vaspin (Serpina12) gene knockout mice. Exon 2 was deleted. Homozygous mutant mice fed with a high-fat-high sucrose diet exhibit increase in body weight, fad pad, liver weight and deterioration of insulin sensitivity.
Colony maintenance Homozygote x Homozygote [or Crossing to C57BL/6JJcl]
Health Report
Gene Details
Promoter No Data
1 Symbol Serpina12
Symbol name serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Chromosome 12
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 12
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
3 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 12
Common name No Data
Symbol description No Data
References

Research applications Cre/loxP system,
Diabetes and Obesity Research
Specific Term and Conditions No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Wada, Jun (Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) Wada, Jun
Strain Status /
Availability
(Expected delivery)


Sperm
Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months