RBRC06232, B6.129S2-Prl<tm1Hmn>

RBRC No. RBRC06232
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129S2-Prl<tm1Hmn>
Former Common name PRL-KO, B6-Prl KO
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
1 Appearance No Data
Genotype No Data
Strain development Developed by Nelson Horseman, University of Cincinnati and Minoru Tanaka, Mie University School of Medicine in 1997. D3 ES cells were used. The mutant mice were backcrossed to C57BL/6 over 20 times.
Strain description Prl (prolaction) gene knockout mice. A PGK-neo cassette was inserted into the exon 4 of Prl gene. Homozygous mutant females are infertile due to an implantation defect. Homozygous mutant males are fertile.
Colony maintenance Heterozygote x Wild-type [C57BL/6J(Crlj)]
Health Report
Gene Details
Promoter No Data
1 Symbol Prl
Symbol name prolactin
Chromosome 13
Common name No Data
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name No Data
Symbol description No Data

Research applications Developmental Biology Research,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
EMBO J., 16, 6926-6935 (1997).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
Additional information
1 No Data
Depositor Tanaka, Minoru (Nippon Veterinary and Life Science University) Tanaka, Minoru
Strain Status /
(Expected delivery)

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months