|Former Common name||DISC1 RGSC1390 – DISC1-L100P, B6-Disc1/1390|
|H-2 Haplotype||No Data|
|Background strain||No Data|
|Strain development||Originated from RIKEN ENU-base gene-driven mutagenesis. Established the B6 congenic strains by Tatiana Lipina and John Roder, Mount Sinai Hospital. The mutant mice were backcrossed to C57BL/6 over 15 times (C57BL/6J and C57BL/6NCrl mixed).|
|Strain description||DISC1 has been reported as a responsible gene for mental illness which was originally found in a large Scottish family with major mental illness such as depression and schizophrenia. Two independently derived ENU-induced mutant mice which have missense mutations in exon 2 of Disc1 gene were developed and analyzed jointly by RIKEN (Japan), University of Edinburgh (UK), and Mount Sinai Hospital (Canada). The mutant mouse with Q31L (Disc1<Rgsc1393>) showed depressive-like behavior with defects, e.g., in the forced swim test. The other mutant mouse with L100P (Disc1<Rgsc1390>) exhibited schizophrenic-like behavior, with profound defect in prepulse inhibition and latent inhibition. These Disc1 missense mutant mice are expected to be very useful as models for depression and schizophrenia. Disc1<Rgsc1390> (L100P)(RBRC06364), Disc1<Rgsc1393> (Q31L)(RBRC06365).|
|Colony maintenance||Homozygote x Homozygote|
|Symbol name||disrupted in schizophrenia 1|
|Common name||No Data|
|Symbol description||No Data|
|Research applications||Mouse Models for Human Disease|
|Specific Term and Conditions||The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Neuron, 54, 387-402 (2007).
The RECIPIENT of for-profit institution must contact the DEPOSITOR separately.
The RECIPIENT of not for-profit institution must contact and discuss in good faith with the DEPOSITOR regarding inventorship, ownership, patent filing and licese fees and others, prior to filing a patent or make a contract with license fees with a third party for invention or products obtained from research results by using the BIOLOGICAL RESOURCES.
|2||Genotyping protocol <PCR>|
|Depositor||RIKEN Genomic Sciences Center|
|Strain Status /