Strain Information | |
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Image | |
BRC No. | RBRC09248 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | CHe.129-Trp53<tm1Brd> |
Former Common name | BALB/c-Trp53 KO, BALB-p53 KO |
H-2 Haplotype | |
ES Cell line | AB1 [129S7/SvEvBrd-Hprt<+>] |
Background strain | BALB/cHeA |
Appearance | |
Strain development | Peter Demant, The Netherlands Cancer Institute to Osaka Prefecture University. The mutant mice were backcrossed to BALB/cHeA over 10 times. |
Strain description | Trp53 knockout mice, BALB/cHeA background. Homozygous mutant mice can grow after birth, but die within a few months after birth due to the development of tumors. |
Colony maintenance | Heterozygote x Wild-type [or Crossing to BALB/cHeAHiOpu (RBRC09247)] |
References | Nature. 356(6366), 215-221 (1992). 1552940 Nature Communications 3492.doi:10.1038/ncomms4492 (2014). 24637670 Oncogene, 18, 4282-4285 (1999). 10435642 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)11mouse polymerase II promoter |
Ordering Information | |
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Donor DNA | Mouse polymerase II promoter, E. coli Neomycin resistance gene, mouse Trp53 genomic DNA |
Research application | Cancer Research |
Specific Term and Conditions | The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. |
Depositor | Nobuko Mori (Osaka Prefecture University) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |