Strain Data Sheet

RBRC10079

Strain Information

Image
BRC No.RBRC10079
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameB6.Cg-Uchl1<gad>/Wada
Former Common namegad mice
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Keiji Wada, National Institute of Neuroscience, NCNP.
Strain descriptionSpontaneous neurological mutant found in the F2 offspring of CBA/Nga and RFM/Nga mice. Mutation was found in the gene, Uchl1 (ubiquitin carboxy-terminal hydrolase L1). C57BL/6J congenic strain by backcrossing over 35 generations. Homozygous mutants exhibit axonal dystrophy and degeneration in the gracile nucleus of the medulla around 2 months old and die around 6 months to 1 year old. Homozygous mutants are difficult to breed.
Colony maintenance
ReferencesHuman Mol. Genetics, 17(10), 1482-1496 (2008). 18250096
Nature Genetics, 23, 47-051 (1999). 10471497

Health Report

Examination Date / Room / Rack

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Uchl1ubiquitin carboxy-terminal hydrolase L15Uchl1<gad>gracile axonal dystrophy

Ordering Information

Donor DNA
Research applicationMouse Models for Human Disease
Neurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature Genetics, 23, 47-051 (1999).
DepositorKeiji Wada (National Center of Neurology and Psychiatry)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-
Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

BRC mice in Publications

No Data