RBRC10391, C.Cg-Xcr1<tm2(HBEGF/Venus)Ksho>

RBRC No. RBRC10391
Type Targeted Mutation CongenicCartagena
Species Mus musculus
Strain name C.Cg-Xcr1<tm2(HBEGF/Venus)Ksho>
Former Common name No Data
H-2 Haplotype No Data
ES cell line Bruce 4 [B6.Cg-Thy1]
Background strain No Data
1 Appearance No Data
Genotype No Data
Strain development Developed by Tsuneyasu Kaisho, Research Center for Allergy and Immunologuy, RIKEN around 2008. BALB/c congenic line. C57BL/6 congenic strain is available as RBRC09485.
Strain description A chemokine receptor, XCR1, is a receptor for XCL1 and expressed dominantly in one dendritic cell subset. XCR1-DTRvenus mice were generated by knocking the gene encoding a fusion protein consisting of human diphtheria toxin receptor (DTR or HBEGF) and a fluorescence protein, venus (derived from Dr. Atsushi Miyawaki at BRI) into the murine XCR1 gene locus. In XCR1-DTRvenus mice, XCR1-expressing cells can be detected by venus expression and ablated transiently by the administration of diphteria toxin.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Frt
Symbol name yeast FRT (flippase recombination target) site
Chromosome 9
Common name No Data
Symbol description No Data
2 Symbol HBEGF
Symbol name heparin-binding EGF-like growth factor (human)
Chromosome 9
Common name No Data
Symbol description No Data
3 Symbol Venus
Symbol name Green Fluorescent Protein, F46L (Jellyfish)
Chromosome 9
Common name No Data
Symbol description No Data
4 Symbol Xcr1
Symbol name chemokine (C motif) receptor 1
Chromosome 9
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
5 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 9
Common name No Data
Symbol description No Data
References No Data

Research applications FLP/frt system,
Fluorescent Proteins/lacZ System,
Immunology and Inflammation Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
1. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form (form D).
2. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.J. Immunol., 190, 6071-6082 (2013).
3. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
4. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the Venus using Approval form (form V) (Lab Contact: Laboratory for Cell Function Dynamics, RIKEN CBS: sakurai-h@brain.riken.jp).
Additional information
1 Approval form Form V (English)
Depositor Kaisho, Tsuneyasu (RIKEN Center for Integrative Medical Sciences (IMS)) Kaisho, Tsuneyasu
Strain Status /
(Expected delivery)

Preparing for distribution
Preparing for distribution

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months

Live mouse :