RBRC01942, B6;129S2-Creb3l4<tm1Noj>

RBRC No. RBRC01942
Type Targeted MutationCartagena wks
Species Mus musculus
Strain name B6;129S2-Creb3l4<tm1Noj>
Former Common name Tisp40 KO mouse
H-2 Haplotype No Data
ES cell line D3 [129S2/SvPas]
Background strain No Data
1 Appearance black
Genotype a/a B/B C/C
Strain development Developed by Norikazu Yabuta and Hiroshi Nojima, Research Institute for Microbial Diseases, Osaka University in 2004. D3 ES cells were used. The mutant mice were crossed to C57BL/6 over 6 times.
Strain description TISP40 (Creb3l4) gene knockout mice. Exons 5 to 10 were replaced with a neo cassette. Homozygous mutant mice are viable and fertile.
Colony maintenance Heterozygote x Homozygote [or Crossing to C57BL/6NCrSlc]
Health Report
Gene Details
Promoter No Data
1 Symbol Creb3l4
Symbol name cAMP responsive element binding protein 3-like 4
Chromosome 3
Common name 1700012K17Rik, 5330432F22Rik, ATCE1, CREB3, CREB4, JAL, mJAL, Tisp40, Tisp40alpha, Tisp40beta
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
2 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 3
Common name neo; neomycin;
Symbol description No Data
References Genes Cells. 2006 Oct;11(10):1161-71.

The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis.
Research applications Cell Biology Research,
Reproductive Biology Research
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Genes to Cells, 11, 1161-1171 (2006).
The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
Additional information
1 No Data
2 Genotyping protocol <PCR>
Depositor Nojima, Hiroshi (Osaka university) Nojima, Hiroshi
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
Tisp40 deficiency attenuates renal ischemia reperfusion injury induced apoptosis of tubular epithelial cells. Exp. Cell Res.359(1): 138-144 (2017).(28778797)
Qin C, Xiao C, Su Y, Zheng H, Xu T, Lu J, Luo P, Zhang J.
Tisp40 deficiency limits renal inflammation and promotes tubular cell proliferation in renal ischemia reperfusion injury. Exp. Cell Res. (2018).(30121191)
Qin C, Li M, Bai T, Yang K, Xu T, Zhang J.