RBRC02479, B6;129S-Hras1<tm1Mok> Grin2a<tm1Nak> Drd1a<tm1Mok> Drd5<tm1Mok>

RBRC No. RBRC02479
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6;129S-Hras1<tm1Mok> Grin2a<tm1Nak> Drd1a<tm1Mok> Drd5<tm1Mok>
Former Common name B6-Hras/NR2A/D1R/D5R KO
H-2 Haplotype No Data
ES cell line CCE/EK.CCE [129S/SvEv-Gpi1]
Background strain No Data
Appearance
1 Appearance No Data
Genotype No Data
Strain development Developed by Motoya Katsuki, National Institutes of Natural Sciences.
Strain description Hras, NR2A (Grin2a), D1R (Drd1a) and D5R (Drd5) genes multiple knockout mice.
Health Report No Data
Gene Details
Promoter No Data
1 Symbol Drd1
Symbol name dopamine receptor D1
Chromosome 13
Common name No Data
Symbol description No Data
2 Symbol Grin2a
Symbol name glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Chromosome 16
Common name No Data
Symbol description No Data
3 Symbol Drd5
Symbol name dopamine receptor 5
Chromosome 5
Common name No Data
Symbol description No Data
4 Symbol Hras
Symbol name Harvey rat sarcoma virus oncogene
Chromosome 7
Common name c-H-ras, c-rasHa, H-ras, Ha-ras, Harvey-ras, Hras-1, ras
Symbol description No Data
5 Symbol neo
Symbol name No Data
Chromosome 7
Common name No Data
Symbol description No Data
Promoter herpes simplex virus thymidine kinase promoter (HSV tk promoter)
6 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 13
Common name neo; neomycin;
Symbol description No Data
7 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 16
Common name neo; neomycin;
Symbol description No Data
8 Symbol neo
Symbol name neomycin resistance gene (E. coli)
Chromosome 5
Common name neo; neomycin;
Symbol description No Data
Promoter mouse phosphoglycerate kinase promoter (PGK promoter)
9 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 13
Common name No Data
Symbol description No Data
10 Symbol Ecogpt
Symbol name E.coli xanthine phosphoribosyltransferase
Chromosome 5
Common name No Data
Symbol description No Data
References J Neurosci. 1996 Dec 15;16(24):7859-67.
Oncogene. 2000 Jun 15;19(26):2951-6.

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.
Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.
Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.
Research applications No Data
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Oncogene, 19, 2951-2956 (2000). J. Neurosci., 16, 7859-7867 (1996). J. Neurosci., 28, 13390-13400 (2008).
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to Dr. Motoya Katsuki is requested. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 No Data
Depositor Sasaoka, Toshikuni (Niigata university) Sasaoka, Toshikuni
Strain Status /
Availability
(Expected delivery)


Preparing for distribution
Preparing for distribution
(Please note that it may take more than 6 months to make arrangements to distribute.)

Frozen
Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months