Strain Information | |
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Image | |
BRC No. | RBRC02767 |
Type | Transgene |
Species | Mus musculus |
Strain name | C57BL/6J-Tg(InsBAC-TRECK/DTR)5Rin |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Kunie Matsuoka and Hiromichi Yonekawa, Tokyo Metropolitan Institute of Medical Science. The transgene was injected into the pronuclei of C57BL/6J fertilized eggs. RBRC02767 (line 5), RBRC02768 (line 14), RBRC02769 (line 17), RBRC02770 (line 33), RBRC02771 (scid background, the same line as the #70 in BBRC2013 article). |
Strain description | INS2(BAC)-TRECK transgenic mice, expressing hDTR cDNA under the control of the mouse insulin II promoter. Hyperglycemia, severe ablation of pancreatic beta cells and depletion of serum insulin were observed within 3 days after the administration of DT. |
Colony maintenance | |
References | Transgenic Res., 21(1):51-62 (2011). 21431867 Biochem. Biophys. Res. Commun., 436, 400-405 (2013). 23747725 |
Health Report | |
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Examination Date / Room / Rack | 2024/01/22Room:3-CRack:D 2023/10/23Room:3-CRack:D |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter HBEGFheparin-binding EGF-like growth factor (human)UNHBEGFmouse Ins2 promoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxPUNloxP Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyAUN Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter rabbit beta-globin polyAUN |
Ordering Information | |
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Donor DNA | Mouse ins2 genomic DNA (RP23-92L23 BAC clone), rabbit beta-globin intron, Human HBEGF cDNA, SV40 polyA, rabbit beta-globin polyA, Phage P1 loxP site from BAC vector |
Research application | Cre/loxP system Diabetes and Obesity Research covid19_progression |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biochem. Biophys. Res. Commun., 436, 400-405 (2013).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT of BIOLOGICAL RESOURCE, who belongs to a profit organization must obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. |
Depositor | Hiromichi Yonekawa (Tokyo Metropolitan Institute of Medical Science) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Live mouse (1 to 3 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |