RBRC04020, B6.129-Dnase2a<tm2.1Osa>

RBRC No. RBRC04020
Type Targeted MutationCartagena
Species Mus musculus
Strain name B6.129-Dnase2a<tm2.1Osa>
Former Common name DNaseII conditional knock out
H-2 Haplotype No Data
ES cell line R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain C57BL/6
1 Appearance No Data
Genotype No Data
Strain description No Data
Health Report
Gene Details
Promoter No Data
1 Symbol Dnase2a
Symbol name deoxyribonuclease II alpha
Chromosome 8
Common name No Data
Symbol description No Data
2 Symbol loxP
Symbol name phage P1 loxP
Chromosome 8
Common name No Data
Symbol description No Data
References Nature. 2006 Oct 26;443(7114):998-1002.

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.
Research applications Cre/loxP system
Specific Term and Conditions The following terms and conditions will be requested by the DEPOSITOR.
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Nature, 443, 998-1002 (2006).
RECIPIENT may only use the BIOLOGICAL RESOURCE for non-commercial academic research purpose. The RECIPIENT should negotiate with the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
Additional information
1 Lab HP
2 Mouse of the Month Aug 2012
Genetic Background
3 Genotyping protocol <PCR>
Depositor Nagata, Shigekazu (Osaka University)
Strain Status /
(Expected delivery)

Cryopreserved embryos : Within 1 month
Recovered litters from cryopreserved embryos : 2-4 months

Cryopreserved sperm : Within 1 month
Recovered litters from cryopreserved sperm : 2-4 months
BRC mice in Publications
Title Journal
DNase II-dependent DNA digestion is required for DNA sensing by TLR9. Nat Commun6: 5853 (2015).(25600358)
Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh S, Ohto U, Shimizu T, Barber GN, Miyake K.